The synthesis of a new strand begins with the synthesis of a(n) _____.

Here is the answer to The synthesis of a new strand begins with the synthesis of a(n) _____.

The synthesis of a new strand begins with the synthesis of a(n) _____.

  • Below are the answer and explanations.

RNA primers

RNA primer is a small segment of RNA, about 10 (5~15) nucleotides in length, synthesized during DNA replication, which is used as a starting point for DNA replication in natural organisms.

Primers (DNA, RNA) refer to polynucleotide chains that function as the starting point for each polynucleotide chain to be extended during the nucleic acid synthesis reaction. On the 3′-OH of the primer, the nucleotide is synthesized as a diester chain, so the 3′-OH of the primer must be free.

The DNA replication process can be broadly divided into three stages: initiation of replication, an extension of the DNA strand, and termination of DNA replication.

The initiation phase of replication includes the unraveling of the double-strand at the start of DNA replication, the synthesis of RNA molecules through a transcriptional activation step, and the synthesis of RNA primers.

In lagging strand synthesis, DNA polymerase adds the first deoxyribonucleotide to the 3′-OH end of the primer RNA. The key step in replication initiation is the synthesis of the leading strand DNA.

In some DNA replication, (e.g. plasmid ColE), this RNA molecule undergoes addition to become the primer for DNA replication. However, in most DNA replication, the RNA molecule has no priming role.

Correct Answer

Here is the correct answer to The synthesis of a new strand begins with the synthesis of a(n) _____.

  • RNA primer complementary to a preexisting DNA strand

The synthesis of a new strand begins with the synthesis of a(n) RNA primer complementary to a preexisting DNA strand.

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